基于Web of Knowledge文献数据平台核心合集(SCI)、TI和Innography,综合应用TDA、SPSS、Excel等软件进行分析,探索肉毒毒素研究领域的发展情况、研究趋势及动态前沿,以期为该领域的决策者制定相关发展策略提供数据支撑,为科研机构及所属人员提供参考。文献计量可视化分析结果显示,肉毒毒素研究主要分布在欧美国家,中国的主要研究力量是军事医学科学院等机构,肉毒毒素主要研究内容为方法检测、预防与应用、疫苗类型及作用机制机理。中国的肉毒毒素研究与国际先进水平尚存在一定差距,应加强基础理论研究以推动专利技术的发展,提高整体研究实力,为应对可能发生的生物恐怖事件提供必要的保障。

To explore the development of botulinum toxin, we analyzed research literature and patent application collected in the database of SCI, TI, Innogarphy of TDA, SPSS, Excel and other softwares. We hope that the visualization analysis can provide data support for policy makers and researchers in the field of botulinum toxin. The results show that main research institutions are distributed in Europe and the United States, and the main force in China is Academy of Military Medical Science. There is still a big gap between China and the developed countries. The main research contents of botulinum toxin are detection, prevention and application, vaccine type and mechanism. We should focus on basic theory and patent technology of botulinum toxin, and improve the ability of preventing terrorist attacks.